Diphtheria and tetanus toxoid vaccine


Generic Medicine Info
Indications and Dosage
Intramuscular
Active immunisation against tetanus and diphtheria
Adult: In patients who have not been immunised previously against tetanus and diphtheria: Primary immunisation: 0.5 mL for 3 doses. The 1st and 2nd dose are given 4-8 weeks apart, then a 3rd dose is given 6-12 months after the 2nd dose. Booster dose: 0.5 mL every 10 years. All doses are to be given via IM inj in the deltoid muscle. Recommendations and vaccination schemes may vary among countries or individual products. Refer to country- or product-specific guidelines.
Child: As diphtheria toxoid 25 limit of flocculation (Lf) and tetanus toxoid 5 Lf per 0.5 mL susp for inj: Infants and children 6 weeks through <7 years In patients with contraindications to pertussis-containing vaccines: Primary series: 0.5 mL for 3 doses given at 2-, 4-, and 6 months of age. Booster dose: 1st dose: 0.5 mL given at approx 15-18 months of age. 2nd dose: 0.5 mL given at 4-6 years of age. As diphtheria toxoid 2 Lf and tetanus toxoid 2 Lf per 0.5 mL susp for inj or diphtheria toxoid 2 Lf and tetanus toxoid 5 Lf per 0.5 mL susp for inj: ≥7 years Same as adult dose. Routine booster immunisation against diphtheria and tetanus is recommended in children 11-12 years and every 10 years thereafter. Recommendations and vaccination schemes may vary among countries or individual products. Refer to country- or product-specific guidelines.

Intramuscular
Prophylaxis of tetanus in wound management
Adult: Treatment and dosage recommendations may vary depending on the immunisation status of the patient (including the time from last tetanus-containing vaccine) and the type and condition of the wound; recommendations may also vary among countries or individual products. Refer to country- or product-specific product guidelines.
Child: ≥7 years Same as adult dose.
Reconstitution
Prior to administration, shake the single-dose vial or syringe well to form a uniform, white, cloudy suspension. Refer to specific product guidelines.
Contraindications
Severe allergic reaction (e.g. anaphylaxis) following a previous dose of this vaccine or any other diphtheria or tetanus toxoid-containing vaccine.
Special Precautions
Patient with bleeding disorders (including thrombocytopenia). Immunocompromised patients. Patient with a history of an Arthus-type hypersensitivity reaction after a previous dose of a tetanus toxoid-containing vaccine should not be given this vaccine more frequently than every 10 years, even for tetanus prophylaxis during wound management. Defer vaccination in patients with moderate or severe acute illness (with or without fever). This vaccine may be available in multiple formulations which may contain different diphtheria and tetanus toxoid concentrations; certain formulations may be specifically used only for children, or adults, and only for primary series or booster doses, refer to specific product guidelines prior to administration. Patient receiving anticoagulant therapy. Children. Pregnancy and lactation.
Adverse Reactions
Significant: Hypersensitivity reactions, anaphylactic reactions, shoulder injury associated with vaccine administration (e.g. shoulder bursitis, tendinopathy), syncope, Guillain-Barre syndrome.
Gastrointestinal disorders: Nausea, diarrhoea.
General disorders and administration site conditions: Inj site reactions (e.g. pain, tenderness, erythema, induration, pruritus, swelling, warmth), pyrexia, peripheral oedema, malaise.
Musculoskeletal and connective tissue disorders: Myalgia, arthralgia, musculoskeletal stiffness or pain.
Nervous system disorders: Dizziness, headache, convulsions.
Skin and subcutaneous tissue disorders: Rash, cellulitis.
Monitoring Parameters
Review the patient's current health status and health history including history of immunisation, the presence of any contraindication to immunisation, and the occurrence of adverse events following previous immunisation prior to vaccination. Monitor for anaphylactic reactions and syncope for 15 minutes after administration.
Drug Interactions
Immunosuppressive therapy (including alkylating agents, antimetabolites, cytotoxic drugs, irradiation, or corticosteroids [in higher doses]) may cause a reduced immune response to the vaccination. May increase the risk of bleeding or haematoma with anticoagulant therapy.
Action
Description: Diphtheria and tetanus toxoid vaccine provides protection against diphtheria and tetanus by inducing the development of neutralising antibodies that combat diphtheria and tetanus toxin.
Storage
Store between 2-8°C. Do not freeze. Protect from light.
MIMS Class
Vaccines, Antisera & Immunologicals
ATC Classification
J07AM51 - tetanus toxoid, combinations with diphtheria toxoid ; Belongs to the class of tetanus bacterial vaccines.
References
Adsorbed DT Vaccine (Propharm [M] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 08/08/2022.

Anon. Diphtheria and Tetanus Toxoids. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 11/10/2022.

Anon. Diphtheria and Tetanus Toxoids. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/08/2022.

Buckingham R (ed). Diphtheria and Tetanus Vaccines. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/08/2022.

Diphtheria and Tetanus Toxoids Adsorbed Injection, Suspension (Sanofi Pasteur Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 11/10/2022.

Seqirus (NZ) Ltd. ADT Booster Diphtheria and Tetanus Vaccine (Adsorbed) for Revaccination data sheet 28 November 2019. Medsafe. http://www.medsafe.govt.nz. Accessed 08/08/2022.

TDVAX Injection (Grifols USA, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 08/08/2022.

Tenivac Injection, Suspension (Sanofi Pasteur Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 08/08/2022.

Disclaimer: This information is independently developed by MIMS based on Diphtheria and tetanus toxoid vaccine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by MIMS.com
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